Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents

J Am Chem Soc. 2005 Apr 6;127(13):4594-5. doi: 10.1021/ja0506509.


A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary alpha-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Catalysis
  • Hydrocarbons, Brominated / chemistry
  • Nickel / chemistry
  • Organometallic Compounds / chemistry*
  • Stereoisomerism
  • Zinc / chemistry*


  • Amides
  • Hydrocarbons, Brominated
  • Organometallic Compounds
  • Nickel
  • Zinc