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Review
. 2005 Apr;26(4):208-14.
doi: 10.1016/j.it.2005.02.002.

Src and Syk Kinases: Key Regulators of Phagocytic Cell Activation

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Review

Src and Syk Kinases: Key Regulators of Phagocytic Cell Activation

Giorgio Berton et al. Trends Immunol. .

Abstract

Src-family kinases and Syk tyrosine kinases have crucial roles in multiple leukocyte intracellular signaling pathways. In immunoreceptor-related pathways, these enzymes work together sequentially, with Src-family kinases phosphorylating specific protein substrates, which in turn recruit and activate Syk. Recent evidence indicates that several non-immunoreceptors also use Src-family kinases and Syk in this same fashion. In leukocyte integrin signaling, the interaction between the kinases is more complex, where they appear to act in a sequential manner but the mechanisms by which they are activated remain poorly defined. Elucidating the regulation of these tyrosine kinase-based signaling pathways in leukocytes remains an important goal in understanding how immune cells respond to the multitude of activating agents they encounter.

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