Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Apr;26(4):208-14.
doi: 10.1016/

Src and Syk Kinases: Key Regulators of Phagocytic Cell Activation


Src and Syk Kinases: Key Regulators of Phagocytic Cell Activation

Giorgio Berton et al. Trends Immunol. .


Src-family kinases and Syk tyrosine kinases have crucial roles in multiple leukocyte intracellular signaling pathways. In immunoreceptor-related pathways, these enzymes work together sequentially, with Src-family kinases phosphorylating specific protein substrates, which in turn recruit and activate Syk. Recent evidence indicates that several non-immunoreceptors also use Src-family kinases and Syk in this same fashion. In leukocyte integrin signaling, the interaction between the kinases is more complex, where they appear to act in a sequential manner but the mechanisms by which they are activated remain poorly defined. Elucidating the regulation of these tyrosine kinase-based signaling pathways in leukocytes remains an important goal in understanding how immune cells respond to the multitude of activating agents they encounter.

Similar articles

See all similar articles

Cited by 66 articles

See all "Cited by" articles

Publication types

LinkOut - more resources