Dosage balance in gene regulation: biological implications

Trends Genet. 2005 Apr;21(4):219-26. doi: 10.1016/j.tig.2005.02.010.


Classical studies in genetics involving aneuploidy and ploidy comparisons and sex-determination mechanisms indicated a balance phenomenon such that changes of individual chromosomal dosage altered the phenotype more dramatically than changes in ploidy. Recent evidence suggests that a major contributor to this balance is the behavior of molecular complexes that function in various regulatory processes affecting gene expression. In this article, we discuss the potential contribution of regulatory balance to the control of quantitative traits, hybrid vigor, genome evolution and post-zygotic speciation mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aneuploidy*
  • Animals
  • Biological Evolution
  • Dosage Compensation, Genetic*
  • Gene Dosage*
  • Gene Expression Regulation / genetics*
  • Humans
  • Phenotype*