Role of Protein and Amino Acids in the Pathophysiology and Treatment of Sarcopenia

J Am Coll Nutr. 2005 Apr;24(2):140S-145S. doi: 10.1080/07315724.2005.10719455.


Sarcopenia, the loss of skeletal muscle mass and function with aging, is a multifactorial condition that slowly develops over decades and becomes a significant contributor to disability in the older population. Malnutrition and alterations in the muscle anabolic response to nutritional stimuli have been identified as potentially preventable factors that may significantly contribute to sarcopenia. Thus, nutritional interventions may be useful for the prevention and treatment of sarcopenia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aged
  • Aging / pathology
  • Aging / physiology*
  • Dietary Proteins / metabolism*
  • Female
  • Humans
  • Male
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiology*
  • Muscular Atrophy / metabolism
  • Muscular Atrophy / pathology*
  • Nutritional Requirements


  • Dietary Proteins