Clinical toxicology study of an herbal medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama) in healthy volunteers

Phytother Res. 2005 Jan;19(1):54-7. doi: 10.1002/ptr.1484.


In Brazil, a herbal medicinal extract named Catuama containing a mixture of Paullinia cupana (guarana; Sapindaceae), Trichilia catigua (catuaba; Meliaceae), Ptychopetalum olacoides (muirapuama; Olacaceae) and Zingiber officinale (ginger; Zingiberaceae) is used as a body stimulant, energetic, tonic and aphrodisiac. The present study investigated the chronic administration of 25 mL Catuama twice a day during 28 days for any toxic effect on healthy human volunteers of both sexes. No severe adverse reactions or haematological and biochemical changes were reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Chemical Analysis
  • Female
  • Humans
  • Male
  • Meliaceae
  • Olacaceae
  • Paullinia
  • Phytotherapy*
  • Plant Extracts / adverse effects
  • Plant Extracts / pharmacology*
  • Plants, Medicinal*
  • Reference Values
  • Zingiber officinale


  • Catuama
  • Plant Extracts