Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver

Corinne Planchamp; Gerd J Beyer; Daniel O Slosman; François Terrier; Catherine M Pastor

doi:10.1016/j.apradiso.2004.11.002

Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver

Appl Radiat Isot. 2005 Jun;62(6):943-9. doi: 10.1016/j.apradiso.2004.11.002. Epub 2005 Jan 7.

Authors

Corinne Planchamp¹, Gerd J Beyer, Daniel O Slosman, François Terrier, Catherine M Pastor

Affiliation

¹ Laboratoire de physiopathologie hépatique, et imagerie moléculaire, Département de Radiologie, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest 24, CH-1211 Genève 14, Switzerland. corrine.planchamp@hcuge.ch

PMID: 15799874
DOI: 10.1016/j.apradiso.2004.11.002

Abstract

The aim was to study the influence of temperature on the transport of the hepatobiliary contrast agent Gadobenate dimeglumine (Gd-BOPTA). Rat livers were isolated and perfused with Gd-BOPTA at 12, 25, 30, 36 and 38 degrees C. After the perfusion period, biopsies were collected and the MR signal intensity was measured. Uptake and biliary excretion were quantified with radiolabeled Gd-BOPTA. MR signal intensity decreased with temperature of perfusion. This phenomenon was appropriately quantified with 153Gd and 153Sm labeling, in contrast to 67Ga.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Contrast Media / pharmacokinetics*
Liver / metabolism*
Meglumine / analogs & derivatives*
Meglumine / pharmacokinetics
Organometallic Compounds / pharmacokinetics*
Rats
Rats, Sprague-Dawley
Temperature*

Substances

Contrast Media
Organometallic Compounds
gadobenic acid
Meglumine