Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver

Appl Radiat Isot. 2005 Jun;62(6):943-9. doi: 10.1016/j.apradiso.2004.11.002. Epub 2005 Jan 7.


The aim was to study the influence of temperature on the transport of the hepatobiliary contrast agent Gadobenate dimeglumine (Gd-BOPTA). Rat livers were isolated and perfused with Gd-BOPTA at 12, 25, 30, 36 and 38 degrees C. After the perfusion period, biopsies were collected and the MR signal intensity was measured. Uptake and biliary excretion were quantified with radiolabeled Gd-BOPTA. MR signal intensity decreased with temperature of perfusion. This phenomenon was appropriately quantified with 153Gd and 153Sm labeling, in contrast to 67Ga.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media / pharmacokinetics*
  • Liver / metabolism*
  • Meglumine / analogs & derivatives*
  • Meglumine / pharmacokinetics
  • Organometallic Compounds / pharmacokinetics*
  • Rats
  • Rats, Sprague-Dawley
  • Temperature*


  • Contrast Media
  • Organometallic Compounds
  • gadobenic acid
  • Meglumine