Abstract
Maintenance of oxygen homoeostasis is the basic principle in cell proliferation, differentiation, survival, and function in all higher organisms. The transcription factor, HIF (hypoxia inducible factor) has a central role in oxygen homoeostasis, and is indispensably linked to energy metabolism. Abnormally reduced oxygen concentrations leading to dysfunctional cell metabolism are found in rheumatoid arthritis and hence, knowledge of the molecular adaptive responses to hypoxia and the involvement of HIF in the pathogenesis of RA are interesting.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Arthritis, Rheumatoid / drug therapy
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Arthritis, Rheumatoid / etiology*
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Arthritis, Rheumatoid / physiopathology
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Cartilage, Articular / metabolism
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Cartilage, Articular / pathology
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Cell Hypoxia* / physiology
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Cyclosporine / therapeutic use
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism*
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Genetic Therapy / methods
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Humans
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Hypoxia / immunology
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Hypoxia / metabolism
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Immunosuppressive Agents / therapeutic use
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Lymphocyte Activation
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Neovascularization, Pathologic
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Nuclear Proteins / chemistry
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Nuclear Proteins / metabolism*
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Oxygen / metabolism*
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Synovial Membrane / immunology
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Synovial Membrane / metabolism*
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Transcription Factors / chemistry
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Transcription Factors / metabolism*
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Vascular Endothelial Growth Factor A / metabolism
Substances
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DNA-Binding Proteins
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HIF1A protein, human
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Immunosuppressive Agents
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Nuclear Proteins
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Transcription Factors
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Vascular Endothelial Growth Factor A
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Cyclosporine
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Oxygen