Chromatin remodelling and epigenetic features of germ cells

Nature. 2005 Mar 31;434(7033):583-9. doi: 10.1038/nature03368.


Germ cells have the unique capacity to start a new life upon fertilization. They are generated during a sex-specific differentiation programme called gametogenesis. Maturation of germ cells is characterized by an impressive degree of cellular restructuring and gene regulation that involves remarkable genomic reorganization. These events are finely tuned, but are also susceptible to the introduction of various types of error. Because stable genetic transmission to future generations is essential for life, understanding the control of these processes has far-reaching implications for human health and reproduction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromatin Assembly and Disassembly / genetics*
  • Epigenesis, Genetic / genetics*
  • Female
  • Germ Cells / metabolism*
  • Histones / chemistry
  • Histones / metabolism
  • Male
  • Molecular Sequence Data
  • Sex Characteristics
  • Transcription, Genetic / genetics


  • Histones