Case-control study of familial lung cancer risks in UK women

Int J Cancer. 2005 Sep 1;116(3):445-50. doi: 10.1002/ijc.21012.


Family history data from a case-control study of lung cancer conducted in the United Kingdom between 1999 and 2004 were analysed to estimate familial risks of the disease. Comparison of lung cancer prevalence in first-degree relatives of 1,482 female lung cancer cases and 1,079 female controls was undertaken using logistic regression adjusting for age and tobacco exposure. Overall, lung cancer in a first-degree relative was associated with a significant increase in the risk of lung cancer [odds ratio (OR) 1.49; 95% confidence interval (CI), 1.13-1.96]. For cases with early onset of the disease (< 60 years), the OR of lung cancer was 2.02 (95% CI, 1.22-3.34). Having 2 or more affected relatives was associated with an OR of 2.68 (95% CI, 1.29-5.55), with a significant trend in risk according to the number of relatives affected (p = 0.001). An increased risk of lung cancer associated with family history of the disease was observed when analysis was restricted to lifetime nonsmokers, although this did not reach significance (OR 1.23; 95% CI, 0.65-2.31). Results confirm previous findings and support the role of a familial predisposition to lung cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Lung Neoplasms / etiology*
  • Lung Neoplasms / genetics*
  • Male
  • Medical History Taking
  • Middle Aged
  • Odds Ratio
  • Pedigree
  • Risk Factors
  • Smoking / adverse effects
  • United Kingdom / epidemiology