Protein targeting by the bacterial twin-arginine translocation (Tat) pathway

Curr Opin Microbiol. 2005 Apr;8(2):174-81. doi: 10.1016/j.mib.2005.02.010.

Abstract

The Tat (twin-arginine translocation) protein export system is found in the cytoplasmic membrane of most prokaryotes and is dedicated to the transport of folded proteins. The Tat system is now known to be essential for many bacterial processes including energy metabolism, cell wall biosynthesis, the nitrogen-fixing symbiosis and bacterial pathogenesis. Recent studies demonstrate that substrate-specific accessory proteins prevent improperly assembled substrates from interacting with the Tat transporter. During the transport cycle itself substrate proteins bind to a receptor complex in the membrane which then recruits a protein-translocating channel to carry out the transport reaction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / metabolism*
  • Bacterial Proteins / metabolism*
  • Escherichia coli / metabolism*
  • Escherichia coli Proteins / physiology*
  • Membrane Transport Proteins / physiology*
  • Protein Transport*

Substances

  • Bacterial Proteins
  • Escherichia coli Proteins
  • Membrane Transport Proteins
  • twin-arginine translocase complex, E coli