CodY, a global regulator of stationary phase and virulence in Gram-positive bacteria

Curr Opin Microbiol. 2005 Apr;8(2):203-7. doi: 10.1016/j.mib.2005.01.001.


Many Gram-positive bacteria encode a homolog of Bacillus subtilis CodY, a protein that controls more than a hundred genes that are typically repressed during rapid growth and induced when cells experience nutrient deprivation. In B. subtilis, the repressor function of CodY is activated by interaction with two different effectors, GTP and isoleucine, which independently and additively increase the affinity of CodY for its target sites. In at least some pathogenic Gram-positive bacteria, major virulence factor genes are among the targets of CodY.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacterial Proteins / physiology*
  • DNA-Binding Proteins / physiology*
  • Gene Expression Regulation, Bacterial*
  • Gram-Positive Bacteria / growth & development*
  • Gram-Positive Bacteria / pathogenicity*
  • Regulon / physiology
  • Repressor Proteins / physiology*
  • Virulence
  • Virulence Factors / biosynthesis*


  • Bacterial Proteins
  • DNA-Binding Proteins
  • Repressor Proteins
  • Virulence Factors