Thrombosis in a pregnant hemophilia A carrier after intrapartum recombinant factor VIII

Obstet Gynecol. 2005 Apr;105(4):875-6. doi: 10.1097/01.AOG.0000141648.05771.24.


Background: Symptomatic hemophilia A is a rare disorder in females. Pregnancy and delivery in such women can be life threatening. Obstetric management is challenging and requires a multidisciplinary approach to ensure a good outcome.

Case: A woman with hemophilia A delivered by cesarean developed a deep vein thrombosis 10 days postpartum after recombinant factor VIII administration.

Conclusion: Hemophilia A due to skewed X-inactivation is a rare cause of peripartum bleeding. Recombinant factor VIII administration can prevent hemorrhage during and after cesarean delivery but may be associated with development of deep vein thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cesarean Section
  • Diagnosis, Differential
  • Factor VIII / administration & dosage*
  • Factor VIII / adverse effects
  • Female
  • Hemophilia A*
  • Heterozygote
  • Humans
  • Pregnancy
  • Pregnancy Complications, Hematologic*
  • Puerperal Disorders / chemically induced
  • Puerperal Disorders / diagnosis*
  • Recombinant Proteins / administration & dosage*
  • Recombinant Proteins / adverse effects
  • Venous Thrombosis / chemically induced
  • Venous Thrombosis / diagnosis*


  • Recombinant Proteins
  • Factor VIII