Communicating with Hedgehogs

Nat Rev Mol Cell Biol. 2005 Apr;6(4):306-17. doi: 10.1038/nrm1622.


Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different thresholds of Hh with distinct responses. The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Drosophila Proteins / genetics
  • Drosophila Proteins / physiology*
  • Drosophila melanogaster / physiology
  • Evolution, Molecular
  • Hedgehog Proteins
  • Humans
  • Intercellular Signaling Peptides and Proteins / physiology
  • Kinesin / physiology
  • Ligands
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • Wnt Proteins


  • Drosophila Proteins
  • Hedgehog Proteins
  • Intercellular Signaling Peptides and Proteins
  • Ligands
  • Receptors, G-Protein-Coupled
  • Trans-Activators
  • Wnt Proteins
  • cos protein, Drosophila
  • hh protein, Drosophila
  • Kinesin