TEC-family kinases: regulators of T-helper-cell differentiation

Nat Rev Immunol. 2005 Apr;5(4):284-95. doi: 10.1038/nri1591.

Abstract

The TEC-family protein tyrosine kinases ITK, RLK and TEC have been identified as key components of T-cell-receptor signalling that contribute to the regulation of phospholipase C-gamma, the mobilization of Ca(2+) and the activation of mitogen-activated protein kinases. Recent data also show that TEC kinases contribute to T-cell-receptor-driven actin reorganization and cell polarization, which are required for productive T-cell activation. Functional studies have implicated TEC kinases as important mediators of pathways that control the differentiation of CD4(+) T helper cells. Here, we review studies of signalling pathways that involve TEC kinases and how these pathways might contribute to the regulation of T-helper-cell differentiation and function.

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Cell Differentiation / immunology
  • Cell Differentiation / physiology*
  • DNA-Binding Proteins / metabolism
  • GATA3 Transcription Factor
  • Humans
  • NFATC Transcription Factors
  • Nuclear Proteins / metabolism
  • Protein Structure, Secondary
  • Protein-Tyrosine Kinases / immunology
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction / immunology
  • Signal Transduction / physiology
  • T-Lymphocytes, Helper-Inducer / cytology
  • T-Lymphocytes, Helper-Inducer / enzymology*
  • T-Lymphocytes, Helper-Inducer / immunology
  • Trans-Activators / metabolism
  • Transcription Factors / metabolism

Substances

  • Actins
  • DNA-Binding Proteins
  • GATA3 Transcription Factor
  • GATA3 protein, human
  • NFATC Transcription Factors
  • Nuclear Proteins
  • Trans-Activators
  • Transcription Factors
  • Tec protein-tyrosine kinase
  • Protein-Tyrosine Kinases
  • emt protein-tyrosine kinase