Mechanisms of B-cell lymphoma pathogenesis

Nat Rev Cancer. 2005 Apr;5(4):251-62. doi: 10.1038/nrc1589.


Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies. Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis. Recent insights into the lymphomagenic role of factors supplied by the microenvironment also offer new therapeutic strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Communication
  • Genes, Immunoglobulin
  • Genes, Tumor Suppressor
  • Germinal Center / physiology
  • Humans
  • Lymphoma, B-Cell / etiology*
  • Lymphoma, B-Cell / genetics
  • Lymphoma, B-Cell / immunology
  • Lymphoma, B-Cell / pathology
  • Mutation
  • Receptors, Antigen, B-Cell / metabolism
  • Signal Transduction
  • Translocation, Genetic


  • Receptors, Antigen, B-Cell