Statins--a cure-all for the brain?

Nat Rev Neurosci. 2005 Apr;6(4):325-31. doi: 10.1038/nrn1652.


'Statins' are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors - oral cholesterol-lowering drugs that are used to treat hypercholesterolaemia. It is widely accepted that statins have anti-inflammatory effects that are independent of their ability to lower cholesterol. Animal studies and observational clinical studies have indicated that statins might also be effective in treating certain neurological diseases - in particular, multiple sclerosis, Alzheimer's disease and ischaemic stroke. At present, however, results from ongoing prospective, randomized clinical trials are not available.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / enzymology
  • Central Nervous System Diseases / drug therapy*
  • Central Nervous System Diseases / enzymology
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors