Chemistry-to-gene screens in Caenorhabditis elegans

Nat Rev Drug Discov. 2005 Apr;4(4):321-30. doi: 10.1038/nrd1692.


The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Antinematodal Agents / pharmacology*
  • Caenorhabditis elegans* / chemistry
  • Caenorhabditis elegans* / genetics
  • Caenorhabditis elegans* / growth & development
  • Drug Design
  • Drug Resistance / genetics
  • Genes, Helminth / genetics*
  • Models, Animal*


  • Antinematodal Agents