Abstract
Several new pyrazolo[3,4-d]pyridazin derivatives were prepared by the reaction of two [corrected] 1H-pyrazole-3-carboxylic acids and various hydrazines. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi. The compounds named as 7e, f had the highest antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi with minimum inhibitory concentrations in the range of 0.31 to<0.0024 mg ml(-1) .
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry*
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Pyrazoles / pharmacology*
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Pyridazines / chemical synthesis
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Pyridazines / chemistry*
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Pyridazines / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Pyrazoles
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Pyridazines
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pyrazolo(3,4-d)pyridazin