Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response

Am J Addict. Jan-Feb 2005;14(1):8-17. doi: 10.1080/10550490590899817.


The prognostic importance of baseline urines for cocaine was examined in a randomized, placebo-controlled, twelve-week clinical trial in 165 opioid- and cocaine-dependent patients who were treated with desipramine (DMI) in combination with buprenorphine (BUP) or methadone (Meth). Patients with a cocaine-positive urine at baseline (CU+) had significantly fewer cocaine-free urines than those with a negative urine at baseline (CU-neg). The CU+ patients showed a treatment effect of DMI. This DMI effect was significant in patients maintained on BUP but not on Meth.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenergic Uptake Inhibitors / therapeutic use*
  • Adult
  • Buprenorphine / therapeutic use
  • Cocaine / urine*
  • Cocaine-Related Disorders / drug therapy*
  • Cocaine-Related Disorders / rehabilitation*
  • Desipramine / therapeutic use*
  • Dopamine Uptake Inhibitors / urine*
  • Female
  • Humans
  • Male
  • Methadone / therapeutic use
  • Middle Aged
  • Narcotic Antagonists / therapeutic use
  • Placebos
  • Predictive Value of Tests
  • Prognosis
  • Treatment Outcome
  • Urinalysis


  • Adrenergic Uptake Inhibitors
  • Dopamine Uptake Inhibitors
  • Narcotic Antagonists
  • Placebos
  • Buprenorphine
  • Cocaine
  • Desipramine
  • Methadone