Role of the Rep helicase gene in homologous recombination in Neisseria gonorrhoeae

J Bacteriol. 2005 Apr;187(8):2903-7. doi: 10.1128/JB.187.8.2903-2907.2005.


In Escherichia coli, the Rep helicase has been implicated in replication fork progression, replication restart, homologous recombination, and DNA repair. We show that a Neisseria gonorrhoeae rep mutant is deficient in the homologous-recombination-mediated processes of DNA transformation and pilus-based colony variation but not in DNA repair.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • DNA Damage / genetics
  • DNA Helicases / physiology*
  • DNA-Binding Proteins / genetics
  • Molecular Sequence Data
  • Neisseria gonorrhoeae / genetics*
  • Recombination, Genetic*
  • Transformation, Bacterial


  • DNA-Binding Proteins
  • DNA Helicases