Pulmonary Langerhans' cell granulomatosis (histiocytosis X)

Annu Rev Med. 1992;43:105-15. doi: 10.1146/annurev.me.43.020192.000541.


Pulmonary Langerhans' cell granulomatosis is usually classified among the lung diseases of unknown origin. Better appreciation of the characteristic clinical features of this disease, more detailed description of the pathologic lesions, and recent advances in the basic biology of Langerhans' cells have provided new insights into the pathogenesis of this process.

Publication types

  • Review

MeSH terms

  • Cell Transformation, Neoplastic / pathology
  • Dendritic Cells / pathology
  • Histiocytosis, Langerhans-Cell / diagnosis*
  • Histiocytosis, Langerhans-Cell / pathology
  • Humans
  • Langerhans Cells / pathology
  • Lung / pathology
  • Lung Diseases / diagnosis*
  • Lung Diseases / pathology
  • Lung Neoplasms / pathology
  • Pulmonary Fibrosis / pathology