Insights into host responses against pathogens from transcriptional profiling

Nat Rev Microbiol. 2005 Apr;3(4):281-94. doi: 10.1038/nrmicro1126.


DNA microarrays have allowed us to monitor the effects of pathogens on host-cell gene expression programmes in great depth and on a broad scale. The comparison of results that have been generated by these studies is complex, and such a comparison has not previously been attempted in a systematic manner. In this review, we have collated and compared published transcriptional-profiling data from 32 studies that involved 77 different host-pathogen interactions, and have defined a common host-transcriptional-response. We outline gene expression patterns in the context of Toll-like receptor and pathogen-mediated signalling pathways, and summarize the contributions that transcriptional-profiling studies have made to our understanding of the infectious disease process.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Bacteria / pathogenicity*
  • Bacterial Infections / genetics
  • Bacterial Infections / immunology
  • Gene Expression Profiling*
  • Gene Expression Regulation*
  • Immunity / genetics
  • Membrane Glycoproteins / metabolism
  • Oligonucleotide Array Sequence Analysis*
  • Receptors, Cell Surface / metabolism
  • Toll-Like Receptors
  • Transcription, Genetic*
  • Virus Diseases / genetics
  • Virus Diseases / immunology
  • Viruses / pathogenicity*


  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors