Circulating YKL-40 levels during human endotoxaemia

Clin Exp Immunol. 2005 May;140(2):343-8. doi: 10.1111/j.1365-2249.2005.02763.x.

Abstract

YKL-40 is secreted by macrophages and neutrophils and patients with bacterial infections have elevated circulating YKL-40. The aim was to evaluate changes in plasma YKL-40 (determined by enzyme-linked immunosorbent assay (ELISA) at 0, 2, 4, 8, 24 and 32 h) in eight healthy volunteers after injection with Esherichia coli endotoxin or saline. Plasma YKL-40 increased after endotoxin injection from 31 microg/l (range 19-39 microg/l) to a maximum of 159 microg/l (61-552 microg/l, P < 0.01) at 24 h. The finding that plasma YKL-40 increased after endotoxin injection compared with saline (P < 0.001) suggests that YKL-40 has a functional role in infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipokines
  • Adult
  • Autoantigens / blood
  • C-Reactive Protein / metabolism
  • Chitinase-3-Like Protein 1
  • Endotoxemia / immunology*
  • Endotoxins / immunology
  • Enzyme-Linked Immunosorbent Assay / methods
  • Escherichia coli / immunology
  • Escherichia coli Infections / immunology*
  • Glycoproteins / blood*
  • Humans
  • Lectins
  • Leukocyte Count
  • Neutrophils / immunology

Substances

  • Adipokines
  • Autoantigens
  • CHI3L1 protein, human
  • Chitinase-3-Like Protein 1
  • Endotoxins
  • Glycoproteins
  • Lectins
  • endotoxin, Escherichia coli
  • C-Reactive Protein