Comparison of fibrin glue and sutures for attaching conjunctival autografts after pterygium excision

Ophthalmology. 2005 Apr;112(4):667-71. doi: 10.1016/j.ophtha.2004.08.028.

Abstract

Purpose: To compare the efficacy and safety of fibrin glue and suturing for attaching conjunctival autografts among patients undergoing pterygium excision.

Design: Prospective, randomized, interventional case series.

Participants: Twenty-two patients undergoing excision of primary pterygium.

Methods: A superior conjunctival autograft was harvested and transferred onto bare sclera after pterygium excision. Fibrin glue (Beriplast P) was used to attach the autograft in 11 eyes and nylon 10-0 suture was used to attach the autograft in 11 eyes. The patients were followed up for 2 months.

Main outcome measures: Graft success, recurrence rate, operating time, patient comfort.

Results: All conjunctival autografts in both groups were successfully attached and were intact after 2 months. The average operating time for the fibrin glue group was significantly shorter (P<0.001). Postoperative symptoms were fewer for the fibrin glue group than the suture group. One patient (9%) from the fibrin group experienced subconjunctival hemorrhage, and 1 patient (9%) from the suture group experienced partial graft dehiscence.

Conclusions: Fibrin glue is a safe and effective method for attaching conjunctival autografts. The use of fibrin glue results in shorter operating times and less postoperative discomfort.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Conjunctiva / transplantation*
  • Female
  • Fibrin Tissue Adhesive*
  • Humans
  • Male
  • Middle Aged
  • Patient Satisfaction
  • Postoperative Complications / prevention & control
  • Prospective Studies
  • Pterygium / surgery*
  • Safety
  • Suture Techniques*
  • Tissue Adhesives*
  • Transplantation, Autologous
  • Treatment Outcome

Substances

  • Fibrin Tissue Adhesive
  • Tissue Adhesives