Multiple sclerosis: novel perspectives on newly forming lesions

Trends Neurosci. 2005 Apr;28(4):173-5. doi: 10.1016/j.tins.2005.01.006.


The mechanisms underlying lesion formation in multiple sclerosis are unknown. The prevailing view is that macrophages are primary mediators of myelin destruction in the relapsing and remitting forms of this disease. However, recent findings have revealed widespread oligodendrocyte apoptosis in the absence of a clear cellular immune response. These observations unveil a novel aspect of the pathogenesis of multiple sclerosis that is worthy of further exploration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Humans
  • Immune System Diseases / complications
  • Immune System Diseases / pathology
  • Models, Biological
  • Multiple Sclerosis / etiology
  • Multiple Sclerosis / pathology*
  • Oligodendroglia / pathology*