The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells

Cancer Lett. 2005 Apr 28;221(2):191-200. doi: 10.1016/j.canlet.2004.08.022.


As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-gamma treatment, but not by TNF-alpha or TGF-beta1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / immunology
  • Adenocarcinoma / therapy
  • Antigens, Differentiation
  • Antineoplastic Agents / pharmacology*
  • Cell Movement / drug effects*
  • Gene Expression Profiling
  • Humans
  • Interferon-gamma / pharmacology*
  • Killer Cells, Natural / drug effects*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Neoplasm Invasiveness / pathology*
  • Stomach Neoplasms / immunology*
  • Stomach Neoplasms / therapy
  • Transforming Growth Factor beta / pharmacology
  • Transforming Growth Factor beta1
  • Tumor Cells, Cultured / drug effects
  • Tumor Necrosis Factor-alpha / pharmacology


  • Antigens, Differentiation
  • Antineoplastic Agents
  • Membrane Proteins
  • TGFB1 protein, human
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1
  • Tumor Necrosis Factor-alpha
  • leu-13 antigen
  • Interferon-gamma