Quinazolines revisited: search for novel anxiolytic and GABAergic agents

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2145-8. doi: 10.1016/j.bmcl.2005.02.023.

Abstract

A systematic approach through computer assisted design to identify novel quinazolines having anxiolytic and GABAergic activity has been reported.

MeSH terms

  • Animals
  • Anti-Anxiety Agents / chemistry*
  • Anti-Anxiety Agents / pharmacology
  • Dose-Response Relationship, Drug
  • GABA Agents / chemistry*
  • GABA Agents / pharmacology
  • GABA Agonists / chemistry
  • GABA Agonists / pharmacology
  • GABA-A Receptor Agonists
  • Maze Learning / drug effects
  • Maze Learning / physiology
  • Mice
  • Quinazolines / chemistry*
  • Quinazolines / pharmacology
  • Receptors, GABA-A / physiology

Substances

  • Anti-Anxiety Agents
  • GABA Agents
  • GABA Agonists
  • GABA-A Receptor Agonists
  • Quinazolines
  • Receptors, GABA-A