Evolution of translational initiation: new insights from the archaea

FEMS Microbiol Rev. 2005 Apr;29(2):185-200. doi: 10.1016/j.femsre.2004.10.002.


Recent in silico and experimental data have shed new light on the mechanism and components of translational initiation in archaea. The available data about the structure of archaeal mRNAs, mRNA/ribosome interaction and archaeal translation initiation factors are reviewed and analyzed in the conceptual framework of the evolution of translational initiation. A model of the initiation step of translation in the Last Universal Common Ancestor of extant cells is presented and discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Archaea / genetics*
  • Codon, Initiator*
  • Evolution, Molecular*
  • Genes, Archaeal
  • Protein Biosynthesis*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism


  • Codon, Initiator
  • RNA, Messenger