Oxygen JNKies: phosphatases overdose on ROS

Dev Cell. 2005 Apr;8(4):452-4. doi: 10.1016/j.devcel.2005.03.005.


Proinflammatory cytokine TNFalpha triggers cell death by inducing reactive oxygen species (ROS). These then inflict cytotoxicity through downstream activation of the JNK MAPK cascade. Yet the mechanisms by which ROS trigger JNK signaling have remained elusive. In a recent issue of Cell, Kamata et al. now provide one such mechanism.

MeSH terms

  • Apoptosis / physiology
  • Enzyme Activation
  • Humans
  • JNK Mitogen-Activated Protein Kinases / metabolism*
  • MAP Kinase Signaling System / physiology
  • Oxygen / metabolism*
  • Phosphoric Monoester Hydrolases / metabolism*
  • Reactive Oxygen Species / metabolism*
  • Receptors, Tumor Necrosis Factor, Type I / metabolism
  • Tumor Necrosis Factor-alpha / metabolism


  • Reactive Oxygen Species
  • Receptors, Tumor Necrosis Factor, Type I
  • Tumor Necrosis Factor-alpha
  • JNK Mitogen-Activated Protein Kinases
  • Phosphoric Monoester Hydrolases
  • Oxygen