[Purification of small peptide from Agkistrodon blomhoffii Bioe and its inhibition on platelet aggregation]

Zhong Yao Cai. 2004 Nov;27(11):840-2.
[Article in Chinese]

Abstract

This is the first report to purify a new peptide SV-PP-1 from Agkistrodon blomhoffii Bioe. SV-PP-1 has molecular weight of 1234.616 Da and can inhibit on platelet aggregation. SV-PP-1 significantly inhibited the ADP-induced platelet aggregation. It has been found up to now that SV-PP-1 is the smallest peptide inhibiting on platelet aggregation from snake venom.

Publication types

  • English Abstract

MeSH terms

  • Agkistrodon*
  • Amino Acid Sequence
  • Animals
  • Dose-Response Relationship, Drug
  • Female
  • In Vitro Techniques
  • Male
  • Materia Medica / isolation & purification
  • Materia Medica / pharmacology*
  • Molecular Weight
  • Peptides / isolation & purification*
  • Peptides / pharmacology*
  • Platelet Aggregation / drug effects
  • Platelet Aggregation Inhibitors / isolation & purification
  • Platelet Aggregation Inhibitors / pharmacology*
  • Rabbits
  • Snake Venoms / chemistry*

Substances

  • Materia Medica
  • Peptides
  • Platelet Aggregation Inhibitors
  • Snake Venoms