Abstract
This is the first report to purify a new peptide SV-PP-1 from Agkistrodon blomhoffii Bioe. SV-PP-1 has molecular weight of 1234.616 Da and can inhibit on platelet aggregation. SV-PP-1 significantly inhibited the ADP-induced platelet aggregation. It has been found up to now that SV-PP-1 is the smallest peptide inhibiting on platelet aggregation from snake venom.
MeSH terms
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Agkistrodon*
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Amino Acid Sequence
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Animals
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Dose-Response Relationship, Drug
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Female
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In Vitro Techniques
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Male
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Materia Medica / isolation & purification
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Materia Medica / pharmacology*
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Molecular Weight
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Peptides / isolation & purification*
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Peptides / pharmacology*
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / isolation & purification
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Platelet Aggregation Inhibitors / pharmacology*
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Rabbits
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Snake Venoms / chemistry*
Substances
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Materia Medica
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Peptides
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Platelet Aggregation Inhibitors
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Snake Venoms