Prospective study of the association of serum triglyceride and glucose with colorectal cancer

Dig Dis Sci. 2005 Mar;50(3):499-505. doi: 10.1007/s10620-005-2464-5.


To determine if serum triglyceride and glucose levels are associated with colorectal cancer, a prospective study among 7619 Japanese-American men was conducted. From 1968 to 1998, 376 colon and 124 rectal cancer incident cases were diagnosed. A strong positive association of alcohol intake and pack-years of cigarette smoking with colorectal cancer was observed. Body mass index and heart rate were also positively related to colon, but not to rectal cancer. In contrast, serum triglyceride did not predict the development of either colon or rectal cancer. There was a modest association of serum glucose in the highest quartile group with rectal cancer (relative risk = 1.33; 95% confidence interval, 0.79-2.26), but it was not statistically significant. This study did not find a strong positive association of serum triglyceride or glucose with colorectal cancer, but additional studies including other metabolic consequences associated with increased serum triglyceride and glucose may clarify the relationship.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Alcohol Drinking
  • Asian / statistics & numerical data
  • Biomarkers, Tumor / blood*
  • Blood Glucose / analysis*
  • Body Mass Index
  • Cohort Studies
  • Colorectal Neoplasms / blood*
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / epidemiology*
  • Confidence Intervals
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Probability
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Assessment
  • Sex Distribution
  • Smoking / adverse effects
  • Survival Analysis
  • Triglycerides / analysis*
  • United States / epidemiology


  • Biomarkers, Tumor
  • Blood Glucose
  • Triglycerides