Current and Emerging Serious Gram-positive Infections

Clin Microbiol Infect. 2005 May;11 Suppl 3:22-8. doi: 10.1111/j.1469-0691.2005.01138.x.


Serious infections caused by Gram-positive pathogens are increasingly difficult to treat because of pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and penicillin-resistant Streptococcus pneumoniae. The more recent emergence of vancomycin-intermediate and -resistant MRSA (VISA and VRSA) has further compromised treatment options. Reports of resistance to, and clinical failures with newer antimicrobial agents such as linezolid and quinupristin/dalfopristin are also emerging. Consequently, there is a clinical need for new antimicrobial agents that have suitable pharmacokinetic properties and safety profiles, with activity against these Gram-positive pathogens.

Publication types

  • Review

MeSH terms

  • Drug Resistance, Bacterial
  • Enterococcus / drug effects
  • Gram-Positive Bacterial Infections / drug therapy*
  • Humans
  • Staphylococcus / drug effects
  • Streptococcus pneumoniae / drug effects