Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons

FEBS Lett. 2005 Apr 11;579(10):2166-70. doi: 10.1016/j.febslet.2005.03.009.


The Na(v)1.6 voltage-gated sodium channel has been implicated in the generation of resurgent currents in cerebellar Purkinje neurons. Our data show that resurgent sodium currents are produced by some large diameter dorsal root ganglion (DRG) neurons from wild-type mice, but not from Na(v)1.6-null mice; small DRG neurons do not produce resurgent currents. Many, but not all, DRG neurons transfected with Na(v)1.6 produce resurgent currents. These results demonstrate for the first time the intrinsic ability of Na(v)1.6 to produce a resurgent current, and also show that cell background is critical in permitting the generation of these currents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Mice
  • Mice, Knockout
  • NAV1.6 Voltage-Gated Sodium Channel
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology*
  • Neurons, Afferent / physiology*
  • Patch-Clamp Techniques
  • Sodium Channels / genetics
  • Sodium Channels / physiology*
  • Spinal Nerves / cytology
  • Spinal Nerves / physiology*


  • NAV1.6 Voltage-Gated Sodium Channel
  • Nerve Tissue Proteins
  • Scn8a protein, mouse
  • Sodium Channels