Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study

Br J Cancer. 2005 Apr 11;92(7):1310-20. doi: 10.1038/sj.bjc.6602491.


Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G>A transitions in rectal tumours.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Case-Control Studies
  • Cohort Studies
  • Colonic Neoplasms / epidemiology
  • Colonic Neoplasms / etiology*
  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / prevention & control
  • DNA Mutational Analysis
  • Diet*
  • Female
  • Genes, ras*
  • Humans
  • Male
  • Meat Products
  • Meat*
  • Middle Aged
  • Netherlands / epidemiology
  • Rectal Neoplasms / epidemiology
  • Rectal Neoplasms / etiology*
  • Rectal Neoplasms / genetics*
  • Rectal Neoplasms / prevention & control
  • Risk Factors
  • Seafood