Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis

Nat Med. 2005 Apr;11(4 Suppl):S33-44. doi: 10.1038/nm1221.


Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis annually cause 3 million and 2 million deaths, respectively. Last year, 600,000 individuals, doubly infected with HIV and M. tuberculosis, died. Since World War I, approximately 150 million people have succumbed to these two infections--more total deaths than in all wars in the last 2,000 years. Although the perceived threats of new infections such as SARS, new variant Creutzfeldt-Jakob disease and anthrax are real, these outbreaks have caused less than 1,000 deaths globally, a death toll AIDS and tuberculosis exact every 2 h. In 2003, 40 million people were infected with HIV, 2 billion with M. tuberculosis, and 15 million with both. Last year, 5 million and 50 million were newly infected with HIV or M. tuberculosis, respectively, with 2 million new double infections. Better control measures are urgently needed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS Vaccines*
  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / prevention & control*
  • Animals
  • Clinical Trials as Topic / legislation & jurisprudence
  • Humans
  • Mycobacterium bovis / genetics
  • Mycobacterium bovis / immunology
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / immunology
  • Tuberculosis / complications
  • Tuberculosis / immunology
  • Tuberculosis / prevention & control*
  • Tuberculosis Vaccines*


  • AIDS Vaccines
  • Tuberculosis Vaccines