Effect of an avocado oil-rich diet over an angiotensin II-induced blood pressure response

J Ethnopharmacol. 2005 Apr 26;98(3):335-8. doi: 10.1016/j.jep.2005.01.044.


We studied the effect of an avocado oil-rich diet on (1) the blood pressure response to angiotensin II (AngII) and (2) the fatty acid composition of cardiac and renal membranes on male Wistar rats. The avocado oil-rich diet induced a slightly higher AngII-induced blood pressure response in the rats as compared to the control rats. In cardiac microsomes, avocado oil induced an increase in oleic acid content (13.18+/-0.33% versus 15.46+/-0.59%), while in renal microsomes, the oil decreased alpha-linolenic acid content (0.34+/-0.02% versus 0.16+/-0.12%), but increased the arachidonic acid proportion (24.02+/-0.54% versus 26.25+/-0.54%), compared to control. In conclusion, avocado oil-rich diet modifies the fatty acid content in cardiac and renal membranes in a tissue-specific manner. The rise in renal arachidonic acid suggests that diet content can be a key factor in vascular responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / pharmacology*
  • Animals
  • Blood Pressure / drug effects*
  • Dietary Fats / pharmacology*
  • Male
  • Microsomes / chemistry
  • Microsomes / drug effects
  • Persea*
  • Plant Oils / pharmacology*
  • Rats
  • Rats, Wistar
  • Vasoconstrictor Agents / pharmacology*


  • Dietary Fats
  • Plant Oils
  • Vasoconstrictor Agents
  • Angiotensin II