Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child

Manola Comar; Pierlanfranco D'Agaro; Douglas Horejsh; Monica Galvan; Simona Fiorentini; Marino Andolina; Arnaldo Caruso; Dario Di Luca; Cesare Campello

doi:10.1128/JCM.43.4.2002-2003.2005

Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child

J Clin Microbiol. 2005 Apr;43(4):2002-3. doi: 10.1128/JCM.43.4.2002-2003.2005.

Authors

Manola Comar¹, Pierlanfranco D'Agaro, Douglas Horejsh, Monica Galvan, Simona Fiorentini, Marino Andolina, Arnaldo Caruso, Dario Di Luca, Cesare Campello

Affiliation

¹ Department of Public Medicine Sciences, University of Trieste, Trieste, Italy.

Abstract

We report a long-lasting (8-month) reactivation of human herpesvirus 6 (HHV-6) infection in child who had undergone cord blood stem cell transplantation. The reactivation was characterized by high viral loads and by immediate-early mRNA positivity. HHV-6 infection was associated with a deep depletion of CD3, while the CD4/CD8 ratio remained substantially unchanged.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

CD3 Complex / metabolism*
CD4-CD8 Ratio
Child
Cord Blood Stem Cell Transplantation / adverse effects*
Herpesvirus 6, Human / physiology*
Humans
Immunologic Deficiency Syndromes / etiology*
Male
Roseolovirus Infections / etiology*
Roseolovirus Infections / virology
T-Lymphocytes / cytology*
Virus Activation

Substances

CD3 Complex