The hemodynamic effects of neonatal patent ductus arteriosus shunting on superior mesenteric artery blood flow

J Perinatol. 2005 Jul;25(7):459-62. doi: 10.1038/


Objective: To determine if the ratio of the pulsatility index (PI) of the left pulmonary artery to the PI of the descending aorta, the Rp/Rs index, correlates with the degree of ductal steal from the intestine in neonates with a patent ductus arteriosus (PDA).

Study design: Echocardiograms and Doppler studies of the superior mesenteric artery (SMA) were performed in 41 neonates less than 35 weeks gestational age with a hemodynamically significant PDA (hsPDA).

Results: There was a significant negative correlation between the Rp/Rs index and the SMA PI after controlling for ductal size (r=-0.476, p<0.008).

Conclusions: The Rp/Rs index can be used as an indicator of ductal steal on intestinal blood flow. The Rp/Rs index may be a useful adjunct to existing and new techniques for improving early assessment and treatment of hsPDA, and for evaluating the effects of hsPDA on systemic organs.

MeSH terms

  • Aorta, Thoracic / diagnostic imaging
  • Aorta, Thoracic / physiopathology*
  • Blood Flow Velocity / physiology
  • Ductus Arteriosus, Patent / physiopathology*
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / physiopathology*
  • Mesenteric Artery, Superior / diagnostic imaging
  • Mesenteric Artery, Superior / physiopathology*
  • Pulmonary Artery / diagnostic imaging
  • Pulmonary Artery / physiopathology*
  • Pulse*
  • Regional Blood Flow / physiology
  • Retrospective Studies
  • Severity of Illness Index
  • Ultrasonography