Microchip technology in ion-channel research

IEEE Trans Nanobioscience. 2005 Mar;4(1):121-7. doi: 10.1109/tnb.2004.842471.

Abstract

The electrical activity of living cells can be monitored in various ways, but for the study of ion channels and the drugs that affect them, the patch-clamp techniques are the most sensitive. Recent developments in microfabricated patch-clamp electrodes are reviewed, and technical challenges for the future are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Action Potentials / physiology*
  • Cell Culture Techniques / instrumentation*
  • Cell Culture Techniques / methods
  • Cell Culture Techniques / trends
  • Equipment Design
  • Ion Channel Gating / physiology*
  • Ion Channels / chemistry
  • Ion Channels / physiology*
  • Lab-On-A-Chip Devices*
  • Membrane Potentials / physiology*
  • Microchip Analytical Procedures / methods
  • Nanotechnology / instrumentation
  • Nanotechnology / methods
  • Patch-Clamp Techniques / instrumentation*
  • Patch-Clamp Techniques / methods
  • Patch-Clamp Techniques / trends
  • Research / instrumentation
  • Research Design

Substances

  • Ion Channels