Functional status and quality of life in patients surviving 10 years after lung transplantation

Am J Transplant. 2005 May;5(5):1099-104. doi: 10.1111/j.1600-6143.2004.00803.x.


Although many lung allograft recipients achieve long-term survival, there is a lack of published data regarding these patients' functional status and quality of life (QoL). We evaluated all 10-year survivors at our institution and, utilizing the SF-36 questionnaire, compared their QoL to population normative and chronic illness data. Twenty-eight (29%) of 96 patients survived > or =10 years following 11 single, 6 bilateral and 11 heart-lung procedures. At the most recent evaluation, median FEV(1) in single and double lung recipients was predicted to be 54% and 74%, respectively. Five (18%) patients had BOS score 0, 13 (46%) BOS 1, 5 (18%) BOS 2 and 5 (18%) BOS 3 and median time to BOS was 7 years. Four (14%) patients required renal replacement therapy. Three patients (11%) developed symptomatic osteoporosis, 2 (7%) post-transplant lymphoma and 1 (4%) an ischaemic stroke. Scores for physical function, role-physical/emotional and general health, but not mental health and bodily pain, were significantly lower compared to normative and chronic illness data. Energy and social-function scores were significantly lower than normative data alone. Long-term survival after lung transplantation is characterized by an absence or delayed development of BOS, low iatrogenic morbidity and preserved mental, but reduced physical health status.

MeSH terms

  • Adolescent
  • Adult
  • Bronchiolitis Obliterans / diagnosis*
  • Bronchiolitis Obliterans / etiology
  • Female
  • Follow-Up Studies
  • Graft Rejection
  • Health Status
  • Health Status Indicators
  • Heart-Lung Transplantation / methods*
  • Heart-Lung Transplantation / psychology*
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Kidney / pathology
  • Lung Transplantation / methods*
  • Lung Transplantation / psychology*
  • Male
  • Neoplasms / etiology
  • Quality of Life
  • Renal Replacement Therapy
  • Surveys and Questionnaires
  • Time Factors
  • Vascular Diseases / etiology


  • Immunosuppressive Agents