Host factors regulating post-integration latency of HIV

Trends Microbiol. 2005 Apr;13(4):137-9. doi: 10.1016/j.tim.2005.02.006.


A recent study has provided important clues towards the identity of the host genes that conspire to promote post-integration latency of human immunodeficiency virus (HIV). Various genes controlling transcription, histone deacetylation and proteasome-mediated protein degradation have emerged as potential players. If the desired, but difficult, goal of complete virus eradication in HIV-infected patients is ever to be realized, the latent reservoir of HIV proviruses must be cleared. Understanding the molecular basis for viral latency is the key first step.

MeSH terms

  • CD4-Positive T-Lymphocytes / physiology
  • CD4-Positive T-Lymphocytes / virology*
  • Gene Expression Regulation, Viral
  • HIV / genetics
  • HIV / physiology*
  • Humans
  • Proviruses / genetics
  • Proviruses / physiology*
  • Virus Integration* / genetics
  • Virus Latency* / genetics