[Efficacy of Intraoperative Hypotonic Peritoneal Chemo-Hyperthermia Combined With Early Postoperative Intraperitoneal Chemotherapy on Gastric Cancer]

Ai Zheng. 2005 Apr;24(4):478-82.
[Article in Chinese]

Abstract

Background & objective: Abdominal recurrence from exfoliated cancer cells contributes a lot to treatment failure of advanced gastric cancer. Intraperitoneal chemotherapy, which has been proved effective in eliminating exfoliated cancer cells in abdominal cavity, is a hot topic on treatment of gastric cancer. This study was to explore application of combined therapy of intraoperative hypotonic peritoneal chemo-hyperthermia and early postoperative intraperitoneal chemotherapy to gastric cancer.

Methods: A total of 156 gastric cancer patients were randomized into 3 groups, and underwent the combined therapy (treatment group 1), intraoperative chemotherapy (treatment group 2), and peritoneal lavage with distilled water (control group), respectively.

Results: The 2-year survival rate of treatment group 1 was significantly higher than that of control group (88.4% vs. 65.2%, P < 0.05). The 3-year survival rate of treatment group 1 was significantly higher than those of treatment group 2, and control group (71.1% vs. 50.0%, and 45.6%, P < 0.05). Occurrence of liver metastasis was significantly lower in treatment groups 1 and 2 than in control group (7.7%, and 10.2% vs. 27.3%, P < 0.05).

Conclusions: Combined therapy of intraoperative hypotonic chemo-hyperthermia and early postoperative intraperitoneal chemotherapy is effective for gastric cancer. Intraperitoneal chemotherapy can be used to prevent postoperative liver metastasis of gastric cancer.

Publication types

  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Female
  • Fluorouracil / administration & dosage
  • Follow-Up Studies
  • Gastrectomy / methods
  • Humans
  • Hyperthermia, Induced*
  • Hypotonic Solutions / administration & dosage
  • Infusions, Parenteral
  • Intraoperative Care
  • Liver Neoplasms / secondary
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Peritoneal Lavage* / methods
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / therapy*
  • Survival Rate

Substances

  • Hypotonic Solutions
  • Cisplatin
  • Fluorouracil