Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction

Am J Cardiol. 2005 Apr 15;95(8):973-5. doi: 10.1016/j.amjcard.2004.12.038.

Abstract

The hypothesis that aspirin resistance is often due to noncompliance was investigated. One hundred ninety patients with a history of myocardial infarction were evaluated using arachidonic acid-stimulated light aggregometry at 3 different time points: while receiving their usual daily aspirin, after not receiving aspirin for 7 days, and 2 hours after the observed ingestion of aspirin 325 mg. At the first time point, 17 patients (9%) failed to show aspirin inhibition of platelet aggregation, but 2 hours after observed aspirin ingestion, aspirin inhibition was observed in all but 1 patient.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arachidonic Acid
  • Aspirin / administration & dosage
  • Aspirin / pharmacology*
  • Aspirin / therapeutic use*
  • Drug Resistance
  • Humans
  • Myocardial Infarction
  • Patient Compliance*
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Aggregation Inhibitors / pharmacology*
  • Platelet Aggregation Inhibitors / therapeutic use*

Substances

  • Platelet Aggregation Inhibitors
  • Arachidonic Acid
  • Aspirin