Mammalian SP/KLF transcription factors: bring in the family

Genomics. 2005 May;85(5):551-6. doi: 10.1016/j.ygeno.2005.01.005.


The advent of the genome projects has provided new avenues to explore the question of how DNA sequence information is used appropriately by mammalian cells. Regulation of transcription is not the only, but is certainly a very important, mechanism involved in this process. We can now identify all the genes encoding transcription factors belonging to a certain class and study their biological functions in unprecedented detail through the use of an array of biomolecular tools. It is important to use rigorous and uniform definitions for the classification of transcription factors, because this helps us to comprehend the functions of transcription factor families in biological networks. Here, we propose an unambiguous nomenclature for the members of the Specificity Protein/Krüppel-like Factor (SP/KLF) transcription factor family.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Computational Biology / methods
  • DNA-Binding Proteins / classification*
  • DNA-Binding Proteins / genetics*
  • Gene Expression Regulation / genetics
  • Genomics / methods
  • Kruppel-Like Transcription Factors
  • Mammals / genetics*
  • Molecular Sequence Data
  • Multigene Family / genetics*
  • Phylogeny
  • Repressor Proteins / classification*
  • Repressor Proteins / genetics*
  • Terminology as Topic*
  • Transcription Factors / classification*
  • Transcription Factors / genetics*


  • DNA-Binding Proteins
  • Kruppel-Like Transcription Factors
  • Repressor Proteins
  • Transcription Factors