Temporal integration of intracellular Ca2+ signaling networks in regulating gene expression by action potentials

Cell Calcium. 2005 May;37(5):433-42. doi: 10.1016/j.ceca.2005.01.011.


Temporal aspects of intracellular calcium signaling are particularly important in activity-dependent regulation of gene expression in neurons. This review traces calcium-dependent intracellular signaling from the membrane to the nucleus in response to action-potential firing, and considers how specific genes are regulated by specific patterns of impulse firing. Modes of calcium influx, calcium-dependent protein kinases, transcription factors, individual genes, and genomic analysis are examined, with particular emphasis on the importance of temporal aspects of calcium dynamics in regulating these processes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Calcium / metabolism*
  • Calcium Signaling / physiology*
  • Gene Expression Regulation / physiology*
  • Humans
  • Intracellular Fluid / chemistry


  • Calcium