Dynamic aspects of presynaptic calcium currents mediating synaptic transmission

Cell Calcium. 2005 May;37(5):507-11. doi: 10.1016/j.ceca.2005.01.018.


Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch of their alpha1 subunits. Dynamic changes of presynaptic VGCCs alter synaptic efficacy, thereby contributing to a variety of modulations of the CNS function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / physiology*
  • Presynaptic Terminals / metabolism*
  • Synaptic Transmission / physiology*


  • Calcium Channels
  • Calcium