Exercise might favor reverse cholesterol transport and lipoprotein clearance: potential mechanism for its anti-atherosclerotic effects

Chen Wei; Meera Penumetcha; Nalini Santanam; Ya-Guang Liu; Mahdi Garelnabi; Sampath Parthasarathy

doi:10.1016/j.bbagen.2005.03.005

Exercise might favor reverse cholesterol transport and lipoprotein clearance: potential mechanism for its anti-atherosclerotic effects

Biochim Biophys Acta. 2005 May 25;1723(1-3):124-7. doi: 10.1016/j.bbagen.2005.03.005. Epub 2005 Mar 22.

Authors

Chen Wei¹, Meera Penumetcha, Nalini Santanam, Ya-Guang Liu, Mahdi Garelnabi, Sampath Parthasarathy

Affiliation

¹ Department of Cardiology, Emory University, Atlanta, GA 30322, United States.

PMID: 15820521
DOI: 10.1016/j.bbagen.2005.03.005

Abstract

Livers of C57 BL/6 mice exercised for 2 weeks showed a dramatic increase in scavenger receptor B1 (SR-B1), CD36 and low density lipoprotein (LDL) receptor and a decrease in acetyl LDL receptor gene expression. These effects on lipoprotein receptors are reminiscent of the effects mediated by peroxisome proliferator-activated receptor (PPARgamma) ligands.

MeSH terms

Animals
Arteriosclerosis / prevention & control*
Biological Transport
CD36 Antigens / genetics
Cholesterol / metabolism*
Lipoproteins / metabolism*
Male
Mice
Mice, Inbred C57BL
PPAR alpha / physiology
PPAR gamma / physiology
Physical Conditioning, Animal*
Receptors, LDL / genetics
Receptors, LDL / physiology

Substances

CD36 Antigens
Lipoproteins
PPAR alpha
PPAR gamma
Receptors, LDL
Cholesterol