Exercise might favor reverse cholesterol transport and lipoprotein clearance: potential mechanism for its anti-atherosclerotic effects

Biochim Biophys Acta. 2005 May 25;1723(1-3):124-7. doi: 10.1016/j.bbagen.2005.03.005. Epub 2005 Mar 22.

Abstract

Livers of C57 BL/6 mice exercised for 2 weeks showed a dramatic increase in scavenger receptor B1 (SR-B1), CD36 and low density lipoprotein (LDL) receptor and a decrease in acetyl LDL receptor gene expression. These effects on lipoprotein receptors are reminiscent of the effects mediated by peroxisome proliferator-activated receptor (PPARgamma) ligands.

MeSH terms

  • Animals
  • Arteriosclerosis / prevention & control*
  • Biological Transport
  • CD36 Antigens / genetics
  • Cholesterol / metabolism*
  • Lipoproteins / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • PPAR alpha / physiology
  • PPAR gamma / physiology
  • Physical Conditioning, Animal*
  • Receptors, LDL / genetics
  • Receptors, LDL / physiology

Substances

  • CD36 Antigens
  • Lipoproteins
  • PPAR alpha
  • PPAR gamma
  • Receptors, LDL
  • Cholesterol