Occludin: structure, function and regulation

Adv Drug Deliv Rev. 2005 Apr 25;57(6):883-917. doi: 10.1016/j.addr.2005.01.009.


Epithelial and/or endothelial barriers play a critical role in animal, including human, life forms. The tight junction (TJ) is an essential component of these barriers. Occludin is a major component of the TJ. The structure of occludin, including its gene splice variants and protein essential components have been elucidated. Phosphorylation/dephosphorylation plays a major role in regulation of occludin and TJ. Disruption of occludin regulation is an important aspect of a number of diseases. Strategies to prevent and/or reverse occludin downregulation may be an important therapeutic target.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Membrane Proteins / biosynthesis
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology*
  • Occludin
  • Structure-Activity Relationship


  • Membrane Proteins
  • OCLN protein, human
  • Occludin