Ashbya gossypii: a model for fungal developmental biology

Nat Rev Microbiol. 2005 May;3(5):421-9. doi: 10.1038/nrmicro1148.

Abstract

Ashbya gossypii is a riboflavin-overproducing filamentous fungus that is closely related to unicellular yeasts such as Saccharomyces cerevisiae. With its close ties to yeast and the ease of genetic manipulation in this fungal species, A. gossypii is well suited as a model to elucidate the regulatory networks that govern the functional differences between filamentous growth and yeast growth, especially now that the A. gossypii genome sequence has been completed. Understanding these networks could be relevant to related dimorphic yeasts such as the human fungal pathogen Candida albicans, in which a switch in morphology from the yeast to the filamentous form in response to specific environmental stimuli is important for virulence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Polarity
  • Genome, Fungal*
  • Humans
  • Riboflavin / biosynthesis
  • Saccharomyces cerevisiae / growth & development
  • Saccharomycetales / genetics*
  • Saccharomycetales / growth & development*
  • Saccharomycetales / physiology
  • Species Specificity

Substances

  • Riboflavin